Bioavailability as a key to remediating PCDD/F-contaminated sites
Official title: Project 5 - Bioavailability as a Central Concept in Determining Remediation Goals and Strategies for PCDD/F-Contaminated Superfund Sites
Funded at Michigan State University · NIH-11394789 · Data updated 2026-11-12
Researchers are studying how tightly PCDD/F toxins stick to soil and sediment particles to guide safer cleanup strategies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | April 1, 1997 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $399,492 |
| NIH project number | 5P42ES004911-31 |
| Project ID | NIH-11394789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to direct patient participation; results could influence risk decisions for communities near contaminated sites and future health studies.
✕Less likely to help
No direct patient participation or immediate clinical benefit in this grant.
What this research studies
This project examines how different soil particle types affect how much of the toxic PCDD/F compounds can reach mammals, including humans. By linking the chemistry of particle surfaces to bioavailability, the work aims to refine risk assessments for contaminated sites. The team uses specialized models and prior lab findings to predict which remediation approaches will best reduce human exposure.
Why it matters
Potential benefit: If successful, the work could lead to more precise cleanup strategies that lower human exposure to toxic PCDD/Fs at contaminated sites.
How similar studies have gone: Previous studies have shown that bioavailability varies with particle type, supporting the potential for improved remediation approaches.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Teppen, Brian John — Michigan State University
- Study coordinator: Teppen, Brian John
Related research
Other NIH-funded projects on the same topics.
-
Understanding how octopuses integrate sensory information and make decisions
This study is exploring how octopuses use their arms to grip things by looking closely at their nervous system and movements, which could help us understand their amazing abilities better.
-
Stabilizing the tear film to relieve evaporative dry eye
This project tests new ways to stabilize the tear film in people with evaporative dry eye, with the goal of longer-lasting comfort.
-
Cell-type specific brain stimulation: new methods to map and predict ICMS effects
A study using targeted brain stimulation and advanced gene mapping to understand how different brain cell types respond to electrical stimulation and how this affects behavior.
-
Expanded program to monitor work injuries and illnesses in Michigan
A nationwide-style occupational health surveillance program will be continued and expanded in Michigan to track injuries, illnesses, and related hazards among workers.
-
Identifying protective antibody responses to malaria in children
Young children in Africa may develop antibodies that protect against malaria; this project maps which antibody features help prevent severe disease.
-
Understanding how viral fusion proteins cause membranes to fuse
Scientists are studying how the envelope proteins of AIDS-causing viruses help them fuse with human cells, with the aim of guiding new antiviral strategies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.