Better Ways to Track Lupus Activity
Monitoring Disease in Lupus
This project looks for specific proteins in body fluids that can help doctors better understand and track lupus in patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11137806 on NIH RePORTER |
What this research studies
Lupus is a complex autoimmune disease that affects many parts of the body, and current treatments don't always lead to full remission. Doctors need easier ways to diagnose lupus, predict how patients will respond to treatment, and understand long-term outcomes. This project aims to find specific proteins in body fluids that act as "biomarkers" to show how active the disease is. Researchers have already found some promising protein markers and are now focusing on a group of ten (called LN-10-plex) that seem to reflect disease activity well. They will test these ten proteins in many more patients from different backgrounds to confirm their usefulness.
Who could benefit from this research
Good fit: Patients with Systemic Lupus Erythematosus (SLE), especially those with varying disease activity or different ethnic backgrounds, would be ideal candidates for this type of research.
Not a fit: Patients without Systemic Lupus Erythematosus would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this could lead to more accurate and easier ways to monitor lupus, helping doctors tailor treatments better for each patient.
How similar studies have performed: The researchers have previously identified and reported serum, cerebrospinal fluid, and excreted proteins for lupus, indicating prior success with similar proteomic approaches.
Where this research is happening
Houston, United States
- University of Houston — Houston, United States (Active)
Researchers
- Principal investigator: Mohan, Chandra — University of Houston
- Study coordinator: Mohan, Chandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.