Better blood transfusions for transplant and blood disease patients
Novel Strategies to Improve Blood Transfusion Practice
['FUNDING_P01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11121915
This project develops ways to make blood transfusions safer and more effective for people having bone marrow or stem cell transplants and others with blood disorders.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11121915 on ClinicalTrials.gov |
What this research studies
If you join this program, researchers will study how transfused red blood cells, platelets, and granulocytes affect the bone marrow and blood-forming stem cells around the time of transplant. They will use patient samples, lab studies, and clinical data from transplant recipients and people with sickle cell disease to learn the cellular and molecular mechanisms. The multidisciplinary team will combine clinical work and laboratory science to test strategies that could change transfusion timing, product choice, or supportive care. The work is centered at Brigham and Women's Hospital and focuses on the high-risk peri-transplant period when transfusion needs are greatest.
Who could benefit from this research
Good fit: Ideal candidates are people undergoing hematopoietic cell transplantation (bone marrow or stem cell transplant) or patients with blood disorders such as sickle cell disease who require transfusion support.
Not a fit: People who do not need blood transfusions or whose health issues are unrelated to blood diseases or transplants are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could reduce transfusion-related complications, lower the number of transfusions needed, and improve recovery after transplant.
How similar studies have performed: While prior clinical work has improved transfusion safety, mechanistic studies in the peri-transplant setting are fairly limited and this coordinated program takes a novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUO, HONGBO R — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: LUO, HONGBO R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, Blood Diseases