Beta-1 blockers to reduce heart injury after brain bleed
Official title: Beta-1 adrenergic inhibition to reduce cardiac injury and inflammation after SAH
Funded at Mainehealth · NIH-11334493 · Data updated 2026-11-12
A patient-focused project aims to use beta-blocker medications to lessen heart damage and inflammation after a non-traumatic brain bleed (subarachnoid hemorrhage).
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | February 10, 2021 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $471,391 |
| NIH project number | 2P20GM139745-06 |
| Project ID | NIH-11334493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have had a non-traumatic subarachnoid hemorrhage and managed in hospital settings with available medical records for analysis.
✕Less likely to help
This study may not directly benefit people who did not have a SAH or whose medical records cannot be accessed for analysis.
What this research studies
If you or a loved one experiences a subarachnoid hemorrhage, this project looks at how overactive nerves may harm the heart and immune system during the hospital stay. Researchers will analyze past patient data to build a simple severity tool for the sympathetic overactivation syndrome and see how it relates to outcomes. They are also examining whether using beta-blocker blood pressure medicines early on could improve recovery. The work uses existing medical records from a large hospital system to identify patterns and guide future treatments.
Why it matters
Potential benefit: If successful, this work could lead to better recognition and management of heart-related complications after SAH, potentially improving recovery.
How similar studies have gone: Preliminary data suggest beta-blockers may mitigate harmful effects of catecholamines after SAH, but a standardized severity tool and systematic analysis are needed.
Where this research is happening
-
Mainehealth
Portland, United States Active
Researchers
- Principal investigator: Puissant, Madeleine M — Mainehealth
- Study coordinator: Puissant, Madeleine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.