BDNF and brain inflammation in veterans’ mental health

Who could benefit from this research

What this research studies

If funded, researchers will explore how BDNF dysfunction relates to neuroinflammation and depressive-like symptoms, focusing on the brain areas and immune pathways involved. The study builds on prior data suggesting two branches of the kynurenine pathway in astrocytes and microglia may drive vulnerability to depression, with potential targets for therapy. Clinically, findings could point to new approaches for treating stress-related mood disorders in veterans who experience high inflammatory burden. The project emphasizes real-world relevance by addressing the veteran population and inflammatory mechanisms that may underlie depressive symptoms.

Why it matters

Where this research is happening

• South Texas Veterans Health Care System
  San Antonio, United States Active

Researchers

• Principal investigator: O'connor, Jason C — South Texas Veterans Health Care System
• Study coordinator: O'connor, Jason C

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.