Asthma and IgE: How nerve signals in the lungs may boost allergy antibodies
Official title: Asthmatic lgE release is due to substance P released by sensory neurons
Funded at Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · NIH-11424686 · Data updated 2026-11-12
A short, patient-friendly study will explore how a nerve-released substance called substance P may push immune cells to make more allergy-causing IgE in asthma.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $245,250 |
| NIH project number | 1R21AI201102-01 |
| Project ID | NIH-11424686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would have asthma with IgE-mediated allergies or subjects that model allergic asthma for future translation.
✕Less likely to help
People without allergic asthma or IgE-driven inflammation may not directly benefit from this study.
What this research studies
This project looks at how nerves in the airways may influence the immune system to produce IgE, a key molecule in allergic asthma. Researchers will study the role of substance P released by sensory neurons and how it affects B cells and IgE production in asthma models. The goal is to understand a new pathway that could be targeted to reduce asthma-triggered inflammation and symptoms. The work includes experiments that connect nerve signals to immune responses in the lungs.
Why it matters
Potential benefit: If successful, findings could lead to new approaches to limit IgE-driven asthma inflammation and improve symptom control.
How similar studies have gone: There is emerging evidence linking neural signals to immune responses in allergic asthma, but the exact pathway to IgE production is still being explored.
Where this research is happening
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Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, United States Active
Researchers
- Principal investigator: Jendzjowsky, Nicholas — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Jendzjowsky, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.