Assay tools and biomarkers for polyamine-related cancers
Official title: Assay Development and Biomarker Discovery
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11453336 · Data updated 2026-11-12
A national team is developing tests and biomarkers to understand how polyamine-related gene changes drive certain cancers and neurodevelopmental disorders, with patient samples helping build better diagnostics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 8, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $557,826 |
| NIH project number | 1U54HD122910-01 |
| Project ID | NIH-11453336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with polyaminopathies or related neurodevelopmental disorders and their biospecimens.
✕Less likely to help
People without polyamine-related disorders may not directly benefit from this research.
What this research studies
This project aims to create a standardized set of laboratory assays and patient data to map how defects in polyamine metabolism affect cells and clinical symptoms. Researchers will develop targeted bioassays and analyze patient samples to identify biomarkers that reflect disease activity and potential treatment targets. The work focuses on conditions like Bachmann-Bupp Syndrome, Faundes-Banka Syndrome, and Snyder-Robinson Syndrome, linking polyamine biology to patient outcomes. By building a shared dataset and validating biomarkers, the effort seeks to enable future trials and precision approaches for affected individuals.
Why it matters
Potential benefit: If successful, patients could gain better diagnostic markers and new targets for therapies.
How similar studies have gone: Previous work on BABS and SRS shows promise, and this project expands to additional polyamine-related conditions.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Bachmann, Andre S — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Bachmann, Andre S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.