Antibody profiling core for dengue vaccines
Official title: Core D: Antibodyomics Core
Funded at University of California Berkeley · NIH-11415544 · Data updated 2026-11-12
A research core at a major university will map the antibody responses in children and vaccinated individuals to understand how dengue antibodies develop and behave.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | July 29, 2015 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $326,142 |
| NIH project number | 5P01AI106695-12 |
| Project ID | NIH-11415544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents in dengue cohorts or vaccine recipients who provide blood samples for immune profiling.
✕Less likely to help
Individuals not enrolled in dengue studies or vaccination cohorts may not directly benefit.
What this research studies
This grant funds Core D to profile antibodies and B cell repertoires in people affected by dengue or vaccinated, using advanced sequencing and mass spectrometry. It collaborates with multiple cohorts, including pediatric dengue cohorts and vaccine studies, to build a comprehensive map of antibody identity and function. The approach combines Ig-seq, BCR-seq, Ab MS, and single-cell sequencing to preserve natural antibody pairs and understand how vaccination or infection shapes immunity. The aim is to generate tools and data that help guide safer and more effective dengue vaccines for children. The work is integrated across several projects and existing cores to create a high-throughput immune profiling platform.
Why it matters
Potential benefit: If successful, this core could accelerate the development of dengue vaccines by revealing which antibodies protect or worsen disease, informing safer vaccine design for children.
How similar studies have gone: Previous immune profiling efforts have shown that detailed antibody repertoires can guide vaccine design, though integrated high-throughput approaches are further developing.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Lavinder, Jason James — University of California Berkeley
- Study coordinator: Lavinder, Jason James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.