Anti-Inflammation and Macrophage Fuel Use After a Heart Attack in Diabetes
Official title: Anti-Inflammatory Roles and Macrophage Metabolism of Lactate and Ketones during Myocardial Infarction
Funded at University of Mississippi Med Ctr · NIH-11386392 · Data updated 2026-11-12
This project looks at how immune cells fuel their activity after a heart attack, especially in people with diabetes, to find new ways to reduce heart damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $584,122 |
| NIH project number | 5R01HL166737-04 |
| Project ID | NIH-11386392 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for diabetes who have experienced a heart attack or are at high risk of myocardial injury may be relevant for future translation and trials.
✕Less likely to help
People without diabetes or those not at risk for heart attack-related heart damage may not benefit from these findings.
What this research studies
If you’ve had a heart attack, your heart’s healing process involves immune cells called macrophages. In diabetes, this healing can go awry and lead to worse heart function. The researchers will study how macrophages use different fuels like lactate and ketones to change from a damaging to a healing state, using advanced metabolic tests in animal models and human-relevant data. The goal is to identify targets that could improve healing and prevent heart failure in diabetic patients. This work could pave the way for new therapies that help the heart recover better after injury.
Why it matters
Potential benefit: If successful, the project could lead to new treatments that improve heart healing after a heart attack, especially for people with diabetes.
How similar studies have gone: Previous work shows macrophage metabolism influences healing after heart injury, with potential for translating metabolic targets into therapies.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Mouton, Alan J — University of Mississippi Med Ctr
- Study coordinator: Mouton, Alan J
Related research
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Anti-inflammatory signaling of a key protein in heart attack recovery
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.