Ang-II Receptors in AgRP Neurons and Resting Metabolism
Official title: Project 2: Ang-II AT1 Receptors in AgRP Neurons: Signal Transduction and Connectome Controlling Resting Metabolism
Funded at Medical College of Wisconsin · NIH-11420077 · Data updated 2026-11-12
A research project aims to understand how a specific brain receptor influences resting metabolism and weight-related biology in adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $564,503 |
| NIH project number | 1P01HL180287-01A1 |
| Project ID | NIH-11420077 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with obesity or metabolic syndrome who could participate in brain-behavior studies or later clinical trials.
✕Less likely to help
Individuals without obesity or metabolic disturbances or those unable to participate in brain-related studies may not receive direct benefit.
What this research studies
This project investigates how angiotensin II signaling in AgRP neurons affects resting metabolic rate and its connection to blood pressure. Researchers will study signal pathways in ARC AgRP cells and how they influence MC4R activity and energy balance. The work builds on prior findings showing that this receptor influences metabolism through a distinct Gi/beta-arrestin cascade. The study is designed to map the connectome and identify key control points that could be targeted to support weight management and cardiovascular health.
Why it matters
Potential benefit: If successful, this work could lead to new approaches to sustain weight loss and improve metabolic health by targeting brain pathways that regulate resting energy use.
How similar studies have gone: Prior work suggests brain-immune-metabolic pathways can modulate resting metabolism, with proof-of-concept data supporting this approach.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Grobe, Justin L — Medical College of Wisconsin
- Study coordinator: Grobe, Justin L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.