Analyzing tissue samples to understand disease-related changes in metabolism
Quantitative Normalization of Spatial Metabolomics for Molecular Signatures of Tissue Heterogeneity
This study is looking at kidney and liver tissue samples to find important changes linked to diseases, using a special technique to help identify potential new ways to understand and treat chronic kidney and liver conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sygnamap, INC. NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10603667 on NIH RePORTER |
What this research studies
This research focuses on using advanced techniques to analyze tissue biopsies, specifically from the kidney and liver, to identify biochemical changes associated with diseases. By employing a method called MALDI-MSI, the researchers aim to quantify the distribution of metabolites in these tissues, which can reveal important disease signatures. The project seeks to develop a computational platform, MSI-DeepPath, that will automate the analysis and improve the accuracy of identifying disease-relevant biomarkers. This could lead to better understanding and treatment options for chronic kidney and liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney or liver diseases who are undergoing tissue biopsies.
Not a fit: Patients with acute kidney or liver conditions, or those not requiring a biopsy, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new therapeutic targets and improved treatment strategies for patients with kidney and liver diseases.
How similar studies have performed: Other research has shown promise in using spatial metabolomics for understanding tissue heterogeneity, indicating that this approach could be effective.
Where this research is happening
San Antonio, United States
- Sygnamap, INC. — San Antonio, United States (Active)
Researchers
- Principal investigator: Hejazi, Leila — Sygnamap, INC.
- Study coordinator: Hejazi, Leila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.