Analyzing how proteins interact and form networks in the body
Genome-wide structure-based analysis of protein-protein interactions and networks
This study is looking at how proteins work together in our bodies, which is important for understanding diseases like bacterial infections, and it hopes to find new ways to create treatments that can help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11251463 on NIH RePORTER |
What this research studies
This research investigates the interactions between proteins and how they form networks that are crucial for various biological processes. By using advanced computational methods and algorithms, the team aims to predict these interactions on a large scale, which can help in understanding diseases caused by bacterial infections and other conditions. The research combines theoretical approaches with experimental validation to uncover the structural basis of these interactions, potentially leading to new insights in systems biology. Patients may benefit from the findings as they could inform the development of targeted therapies for bacterial infections and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections or related diseases where protein interactions play a significant role.
Not a fit: Patients with non-bacterial infections or conditions unrelated to protein interactions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for bacterial infections and improve our understanding of protein functions in health and disease.
How similar studies have performed: Previous research in computational structural biology has shown promise in understanding protein interactions, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Honig, Barry H — Columbia University Health Sciences
- Study coordinator: Honig, Barry H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.