Analyzing genetic factors in coronary artery disease and atherosclerosis
Whole-genome sequencing analysis of coronary atherosclerosis and related traits
This study is looking at how our genes might affect heart problems and artery health, especially in people from different backgrounds, to help better predict who might be at risk and find ways to prevent these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10786048 on NIH RePORTER |
What this research studies
This research investigates the genetic underpinnings of coronary artery disease (CAD) and subclinical atherosclerosis by utilizing whole-genome sequencing. It aims to identify both common and rare genetic variants that contribute to these conditions, focusing on diverse populations beyond those of European ancestry. By examining genetic data, the study seeks to enhance risk prediction models for CAD, potentially leading to improved prevention strategies for at-risk individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of coronary artery disease or those diagnosed with subclinical atherosclerosis.
Not a fit: Patients without any cardiovascular risk factors or those who do not have a family history of coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic risk assessments and personalized prevention strategies for coronary artery disease.
How similar studies have performed: Previous genome-wide association studies have successfully identified genetic variants linked to coronary artery disease, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: De Vries, Paul Stefan — University of Texas Hlth Sci Ctr Houston
- Study coordinator: De Vries, Paul Stefan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.