Alzheimer's Prevention Initiative ADAD Colombia Trial Program
Funded at Banner Health · NIH-11394346 · Data updated 2026-11-12
A large NIH-funded effort is testing an approach to prevent Alzheimer's disease in people carrying a genetic mutation in Colombia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Banner Health NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $20,993,265 |
| NIH project number | 5R01AG086363-03 |
| Project ID | NIH-11394346 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are individuals with the PSEN1 E280A mutation or other ADAD family members willing to participate in long-term prevention studies.
✕Less likely to help
People without the ADAD mutation or those unwilling to commit to long-term follow-up may not benefit.
What this research studies
This project focuses on people with a specific inherited form of Alzheimer's to test prevention strategies over several years. Researchers have built clinical trial infrastructure, imaging, and specimen-sharing systems in Colombia to study when and how the disease might be delayed or stopped. The study engages individuals who are very likely to develop dementia and follows them to understand biomarker changes and clinical outcomes. The results could illuminate how early interventions might alter the disease course for high-risk individuals and possibly for others in the future.
Why it matters
Potential benefit: If successful, the trial could slow or prevent cognitive decline in people at high genetic risk for Alzheimer's, potentially changing the standard of care.
How similar studies have gone: Previous AD prevention trials in similar high-risk groups have shown feasibility and meaningful biomarker changes, though this exact approach is ongoing.
Where this research is happening
-
Banner Health
Phoenix, United States Active
Researchers
- Principal investigator: Alexander, Robert C — Banner Health
- Study coordinator: Alexander, Robert C
Related research
Other NIH-funded projects on the same topics.
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Alzheimer’s Prevention Initiative in Colombia ADAD trial
A study in Colombia aims to test ideas to prevent Alzheimer’s in people who carry a genetic mutation that almost guarantees they will develop the disease.
-
Tracer harmonization for amyloid and tau PET imaging using statistics and deep learning
Aims to make PET brain scans for Alzheimer's disease more comparable across different tracers so doctors can better use the results for diagnosis and treatment decisions.
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Preventing early-onset Alzheimer's in a large Colombian family with a PSEN1 mutation
This program tries treatments that remove amyloid to delay or prevent memory loss in people from a Colombian family who carry a PSEN1 mutation that causes early Alzheimer's.
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Standardizing amyloid and tau PET brain scans
The team will create methods to make amyloid and tau PET brain scans more comparable so people being checked for Alzheimer’s get clearer, more consistent results.
-
Preventing Alzheimer's in a Colombian family with an inherited PSEN1 gene change
This project tests whether treatments that lower brain amyloid can delay or prevent Alzheimer's in people from a Colombian family who carry a genetic mutation that usually causes dementia in midlife.
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Improving online Alzheimer's research registries to connect people with studies
This project builds better websites and tools to help older adults and their caregivers find and join Alzheimer's prevention and treatment research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.