Allelic Dio3 control of brain development and behavior in mood and neurodevelopmental disorders
Official title: Allelic Dio3 control of brain development and behavior
Funded at Mainehealth · NIH-11305356 · Data updated 2026-11-12
A research project explores how a gene called Dio3 might shape brain development and behavior, potentially helping people with mood and neurodevelopmental conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | June 24, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $466,738 |
| NIH project number | 1R01MH139529-01A1 |
| Project ID | NIH-11305356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with affective or neurodevelopmental conditions, including ADHD, ASD, or mood disorders, and appropriate adult or adolescent participants as determined by the study.
✕Less likely to help
People without neurodevelopmental or affective disorders are unlikely to directly benefit from this grant.
What this research studies
This project looks at how variations in the Dio3 gene and thyroid hormone signaling during brain development might contribute to conditions like autism, ADHD, and mood disorders. Researchers will examine genetic expression, epigenetic factors, and sex differences to understand why these disorders emerge and affect males and females differently. The study uses human-relevant approaches and may involve analysis of brain development processes and related data to uncover potential targets for prevention and treatment. By studying how environmental influences could alter gene activity, the work aims to reveal new insights into the origins of neurodevelopmental and affective disorders.
Why it matters
Potential benefit: If successful, the research could identify new genetic or developmental pathways that lead to mood and neurodevelopmental disorders, guiding earlier diagnosis and new therapeutic strategies.
How similar studies have gone: Previous work shows that genetic and epigenetic factors influence brain development and psychiatric risk, but the Dio3-specific pathway remains to be clarified.
Where this research is happening
-
Mainehealth
Portland, United States Active
Researchers
- Principal investigator: Hernandez, Arturo — Mainehealth
- Study coordinator: Hernandez, Arturo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.