AI-based prediction of heart attack, stroke, and heart failure risk across different populations
SCH: Transfer Regression to Enable Cross-Domain Cardiovascular Event Prediction
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11174500
This project builds a fairness-aware AI tool to predict the risk of heart attack, stroke, heart failure, or death for people at risk of atherosclerotic cardiovascular disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11174500 on ClinicalTrials.gov |
What this research studies
Researchers are building an AI model that learns from multiple large health datasets to predict major cardiovascular events like heart attack, stroke, heart failure, or death. The team will use a new transfer regression method so the model can adapt when applied to different hospitals, populations, or screening programs. The approach prioritizes fairness and uses commonly available, low-cost screening tests that are quick and low-risk. The model's accuracy and robustness will be tested using four large, diverse datasets before any clinical rollout.
Who could benefit from this research
Good fit: Adults with risk factors for atherosclerotic cardiovascular disease or those undergoing routine cardiovascular screening would be the main candidates for this work.
Not a fit: People without cardiovascular risk factors or those outside the populations represented in the training datasets may not benefit from the model's predictions.
Why it matters
Potential benefit: If successful, this tool could help identify people at higher risk earlier so clinicians can offer targeted preventive treatments.
How similar studies have performed: Other AI risk models for cardiovascular events exist, but this transfer-regression approach to ensure cross-population performance is novel and not yet proven in practice.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, SHUO — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: LI, SHUO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease