Aging-related platelet production: how aging changes blood clotting cells from stem cells
Official title: Defining the cause and consequence of aging-specific platelet specification from hematopoietic stem cells
Funded at University of California Santa Cruz · NIH-11333738 · Data updated 2026-11-12
Aging changes how blood platelets are made and function, and this study looks at the cells that give rise to platelets to understand why older adults have more bleeding or clotting problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project start | September 15, 2019 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $657,298 |
| NIH project number | 5R01AG062879-08 |
| Project ID | NIH-11333738 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with age-related blood clotting disorders or those at risk of thrombosis may benefit from insights gained, once translated to human studies.
✕Less likely to help
Healthy young individuals with no risk of platelet disorders may see limited immediate benefit.
What this research studies
As we age, platelets can become abnormal, increasing the risk of bleeding or clotting events. This project will explore how aging changes the pathways that hematopoietic stem cells use to produce platelets and how those changes affect platelet function. By studying mouse models and aging-related molecular processes, researchers aim to uncover why older individuals are more prone to platelet-related disorders and identify potential targets to improve platelet health with age.
Why it matters
Potential benefit: Understanding aging-related platelet changes could lead to new strategies to reduce bleeding and clotting risks in older adults.
How similar studies have gone: Previous work shows that aging alters blood cell development, with some studies hinting at age-specific pathways in platelet production.
Where this research is happening
-
University of California Santa Cruz
Santa Cruz, United States Active
Researchers
- Principal investigator: Forsberg, Camilla — University of California Santa Cruz
- Study coordinator: Forsberg, Camilla
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.