Aging and neutrophil protection in the female genital tract
Official title: The impact of aging on neutrophil-mediated protection and inflammation in the female genital mucosa
Funded at Wayne State University · NIH-11378574 · Data updated 2026-11-12
This grant looks at how aging changes the immune protection in the female genital tract, focusing on neutrophils and their early responses to infections.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $515,285 |
| NIH project number | 5U01AG084766-03 |
| Project ID | NIH-11378574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older or younger women at risk for urogenital infections, including sexually transmitted infections, who could contribute tissue samples or data.
✕Less likely to help
If you do not have or are not at risk for urogenital infections, you may not directly benefit.
What this research studies
As a patient, you would be part of a study using advanced lab methods to understand how aging affects neutrophil function in the female genital tract. Researchers will examine how neutrophils respond to infections and how this may differ between younger and older women. The study uses samples and cutting-edge technologies to reveal immune mechanisms that could inform new prevention strategies for genital infections and sexually transmitted infections across ages. The goal is to identify protective signals that work in younger and older women so future interventions can be tailored to age-related needs.
Why it matters
Potential benefit: Findings could lead to age-specific approaches to prevent genital infections and improve mucosal immune protection.
How similar studies have gone: Preliminary work suggests neutrophils play a protective role in the genital tract, with aging altering antiviral responses; this area is actively evolving.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Rodriguez Garcia, Marta — Wayne State University
- Study coordinator: Rodriguez Garcia, Marta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.