Advancing the Xiphophorus Fish Model for Studying Disease
Official title: Advancement of the Xiphophorus Model for Studying Disease
Funded at Texas State University · NIH-11334706 · Data updated 2026-11-12
A grant to improve a fish model (Xiphophorus) so researchers can study human disease more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas State University NIH-funded |
| Lab location | 1 site (San Marcos, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $755,528 |
| NIH project number | 2R24OD031467-05 |
| Project ID | NIH-11334706 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant does not involve direct patient participation; it focuses on building resources and tools for biomedical researchers using the Xiphophorus model.
✕Less likely to help
No direct patient participation or treatment is involved in this grant.
What this research studies
This project will make the Xiphophorus fish a more useful model by standardizing resources, adding fresh lab tools, and sharing data widely. Researchers will assign unique identifiers (RRIDs), integrate data into open platforms, and create a data archive to keep information accessible. The team will develop primary cell cultures, tissue-specific transcription maps, and a microfluidic organ-on-a-chip system to enable better in vitro studies. They will also build a viral vector toolkit with a Cas9 transgenic line to support genome editing in Xiphophorus. Altogether, these efforts aim to accelerate discoveries about gene function and disease mechanisms using this model.
Why it matters
Potential benefit: If successful, patients could benefit indirectly through faster translation of basic discoveries into disease understanding and potential therapies.
How similar studies have gone: Other model-organism resource-development efforts have improved research adoption and reproducibility, with positive impact on downstream disease studies.
Where this research is happening
-
Texas State University
San Marcos, United States Active
Researchers
- Principal investigator: Lu, Yuan — Texas State University
- Study coordinator: Lu, Yuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.