Smc5/6 protein sumoylation and DNA repair mechanism in cancer
Official title: Mechanism of Smc5/6-mediated protein sumoylation in DNA repair
Funded at Texas State University · NIH-11386552 · Data updated 2026-11-12
A study at Texas State University will explore how a specific protein complex helps repair DNA in cancer cells, which could lead to new ways to prevent genome instability.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas State University NIH-funded |
| Lab location | 1 site (San Marcos, United States) |
| Project start | August 15, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $148,228 |
| NIH project number | 5R16GM159631-02 |
| Project ID | NIH-11386552 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancers characterized by defective DNA repair or altered sumoylation pathways.
✕Less likely to help
This basic science project does not involve testing new treatments in patients; it focuses on molecular mechanisms.
What this research studies
This project looks at how the Smc5/6 complex and its partners attach SUMO molecules to repair proteins during DNA damage, a process that keeps cancer cells from accumulating harmful changes. Researchers will combine cellular data with molecular approaches to understand how ATP hydrolysis and DNA binding influence this sumoylation step. The aim is to map how different parts of Smc5/6 work together to regulate homologous recombination repair at damage sites. Insights from this work could point to new targets for therapies that exploit faulty DNA repair in cancers.
Why it matters
Potential benefit: If successful, the work could identify new molecular targets to improve cancer treatment by leveraging DNA repair pathways.
How similar studies have gone: Similar research on SUMOylation and DNA repair has provided foundational knowledge, supporting the potential for impactful discoveries with this approach.
Where this research is happening
-
Texas State University
San Marcos, United States Active
Researchers
- Principal investigator: Xue, Xiaoyu — Texas State University
- Study coordinator: Xue, Xiaoyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.