Advanced technology for studying protein structures and interactions
Official title: Pulsed Q-band Electron Paramagnetic Resonance Spectrometer for Structural Biology Applications
Funded at Northwestern University · NIH-10869435 · Data updated 2026-11-12
This study is all about getting a new, high-tech machine that helps scientists at Northwestern University and nearby to better understand how proteins work and interact, which is important for creating new medicines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,899,161 |
| NIH project number | 1S10OD036453-01 |
| Project ID | NIH-10869435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions related to protein misfolding or dysfunction, such as neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein structure or function may not receive direct benefits from this research.
What this research studies
This research focuses on acquiring a cutting-edge Pulsed Q-band Electron Paramagnetic Resonance (EPR) spectrometer to enhance the understanding of protein structures and their interactions. The instrument will be available for use by researchers at Northwestern University and the greater Chicago area, facilitating studies on both folded and intrinsically disordered proteins, as well as biomolecular assemblies. By utilizing advanced techniques such as Double Electron Electron Resonance (DEER) and Electron Nuclear Double Resonance (ENDOR), the research aims to provide detailed insights into molecular structures and dynamics that are crucial for developing new therapeutic agents.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in the development of novel therapies for various diseases by improving our understanding of protein interactions.
How similar studies have gone: Previous research utilizing EPR spectroscopy has shown promising results in understanding protein dynamics and interactions, indicating that this approach is both validated and effective.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Han, Songi — Northwestern University
- Study coordinator: Han, Songi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.