Advanced MRI to monitor knee joint health after an ACL tear
Multinuclear MRI to Assess Joint Homeostasis after Knee Injury
This project uses a special MRI that images both water and sodium in knee cartilage to learn how joints change after an ACL tear or reconstruction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11233249 on NIH RePORTER |
What this research studies
You would get new MRI scans that capture both proton (water) and sodium signals to show structural and biochemical changes in knee cartilage. Doctors will also collect small samples of joint fluid and measure your knee strength and activity to link those lab markers with the images. The team will compare these measures early after injury to how the knee looks and works later on to spot patterns that lead to osteoarthritis. The goal is to find early changes that could guide treatments before lasting joint damage develops.
Who could benefit from this research
Good fit: Ideal participants are people who recently experienced an ACL tear or who have had ACL reconstruction and are willing to undergo MRI scans, joint fluid collection, and strength/activity testing.
Not a fit: People without an ACL injury, those with long-standing advanced osteoarthritis, or anyone unable to have MRI scans or joint-fluid sampling are unlikely to benefit from participating.
Why it matters
Potential benefit: If successful, this could help detect early cartilage damage and guide care to reduce the chance of post-traumatic osteoarthritis after an ACL injury.
How similar studies have performed: Related work using MRI and biochemical markers has shown links to cartilage health, but the simultaneous proton/sodium MR fingerprinting approach in this project is new and less tested in patients.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Madelin, Guillaume — New York University School of Medicine
- Study coordinator: Madelin, Guillaume
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.