Advanced light-based imaging to map complex biology
Official title: Super-multiplex optical imaging: development of novel spectroscopy and probes to illuminate complex biomedicine
Funded at Columbia Univ New York Morningside · NIH-11401699 · Data updated 2026-11-12
A new imaging platform will let researchers see many different molecules and cells at once, with high detail, to better understand how biological systems work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $627,732 |
| NIH project number | 5R35GM149256-04 |
| Project ID | NIH-11401699 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with neurological conditions or diseases where tissue-level changes and cellular interactions are important, such as brain-related disorders, could be impacted by future capabilities built on this research.
✕Less likely to help
This work focuses on developing imaging technology, so patients may not directly receive a treatment or diagnosis from this grant.
What this research studies
This project aims to develop a groundbreaking imaging technology that can watch many targets inside living tissues in three dimensions and over time. It will use advanced spectroscopy methods to break previous color barriers and achieve single-molecule sensitivity. By enabling simultaneous observation of proteins, organelles, and cell types, patients’ future diagnoses and treatments could benefit from deeper biological insight.
Why it matters
Potential benefit: If successful, the technology could lead to more precise diagnoses and personalized therapies by revealing complex biological interactions inside the body.
How similar studies have gone: Earlier imaging approaches show promise, but this project seeks to surpass current limits with a more powerful, multi-target platform.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Min, Wei — Columbia Univ New York Morningside
- Study coordinator: Min, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.