Advanced imaging technology for studying live embryos in 3D
Official title: Instrument Grant for Truelive 3D
Funded at University of California Berkeley · NIH-10854001 · Data updated 2026-11-12
This study is all about using a special microscope to take super clear, 3D pictures of live embryos from mice, flies, and zebrafish, so scientists can watch how their cells grow and interact without harming them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $942,983 |
| NIH project number | 1S10OD036267-01 |
| Project ID | NIH-10854001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals interested in developmental biology, particularly those with conditions related to embryonic development or cellular dysfunction.
✕Less likely to help
Patients with conditions unrelated to embryonic development or cellular biology may not receive direct benefits from this research.
What this research studies
This research focuses on acquiring a state-of-the-art light-sheet microscope designed for high-resolution, three-dimensional imaging of live embryos and other delicate specimens. By utilizing the TruLive3D Imager, researchers aim to capture rapid time-lapse images of mouse, fly, and zebrafish embryos in their natural environments, allowing for detailed observation of cellular processes without damaging the samples. This innovative approach will enable developmental, cell, and molecular biologists to explore complex cellular behaviors and interactions in real-time.
Why it matters
Potential benefit: If successful, this research could significantly enhance our understanding of embryonic development and cellular functions, leading to advancements in biomedical research and potential therapeutic applications.
How similar studies have gone: Other research has successfully utilized advanced imaging technologies to study cellular processes, indicating a promising potential for this novel approach.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: He, Lin — University of California Berkeley
- Study coordinator: He, Lin
Related research
Other NIH-funded projects on the same topics.
-
Mobile AI-powered microscope to quickly spot parasites in wastewater
A new AI-enabled mobile microscope will be tested to quickly detect parasite eggs in wastewater from refugee settings to help protect public health.
-
SCAN: Standardized brain imaging for Alzheimer’s and related dementias
A nationwide effort to standardize brain imaging data in people with Alzheimer’s and related dementias so researchers can compare results and learn how to diagnose and track the disease.
-
Cerebellum’s role in thinking and behavior across tasks
This grant explores how the cerebellum helps people think, feel, and behave across different tasks, with a focus on understanding cognitive and affective processing in cerebellar disorders.
-
Genetic clues to how teeth form and replace themselves in sticklebacks
A study in a fish model aims to uncover the genetic factors that control how teeth form and keep renewing, with potential implications for human tooth regeneration.
-
California Abundant Birth Project: does guaranteed income during pregnancy affect birth outcomes and child development?
A government-backed program gives pregnant people in California monthly income to reduce stress, with researchers studying how this helps birth outcomes and early child development.
-
American-Asian Arbovirus Research and Enhanced Surveillance Center
A2CARES is a national program that brings together scientists across disciplines to improve detection, study, and response to arthropod-borne viruses affecting adults in the Americas and Asia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.