Advanced imaging techniques for observing cellular activities in deep tissues
Official title: Fast Multi-Functional 3D Imaging of Cellular Activities in Deep Tissue
Funded at University of Arizona · NIH-10990024 · Data updated 2026-11-12
This study is working on a new type of microscope that can take super clear and fast pictures of how cells behave inside deep tissues, like in zebrafish and mice, to help us learn more about important processes in our bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $505,582 |
| NIH project number | 1R01EB034921-01A1 |
| Project ID | NIH-10990024 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions affecting cellular signaling or tissue function, particularly those related to kidney or neurological disorders.
✕Less likely to help
Patients with superficial tissue conditions or those not affected by cellular signaling issues may not receive direct benefits from this research.
What this research studies
This research focuses on developing a cutting-edge microscopy instrument that allows for high-speed, high-resolution imaging of cellular activities within deep tissues. By utilizing advanced techniques such as two-photon Bessel beam light sheet microscopy, the project aims to capture detailed images of cellular dynamics in live models, including zebrafish and mice. The instrument will enable simultaneous imaging of various cellular signals, providing insights into processes like calcium and cAMP activities in real-time. This innovative approach could significantly enhance our understanding of cellular functions in complex biological environments.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular activities in deep tissues, potentially improving diagnosis and treatment of various diseases.
How similar studies have gone: Other research has shown success with advanced imaging techniques in similar contexts, indicating a promising potential for this novel approach.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Peng, Leilei — University of Arizona
- Study coordinator: Peng, Leilei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.