Advanced culture and recording system for long-term brain organoid activity
Official title: Advanced culture and recording system for long-term electrophysiological profiling in human brain organoids
Funded at Neuronexus Technologies · NIH-11291833 · Data updated 2026-11-12
A new, user-friendly system will let researchers measure brain organoids’ electrical activity over weeks, helping scientists study how brain cells develop and respond to drugs.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neuronexus Technologies NIH-funded |
| Lab location | 1 site (Ann Arbor, UNITED STATES) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2026 |
| Award (this year) | $449,677 |
| NIH project number | 5R43MH139259-02 |
| Project ID | NIH-11291833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include labs and researchers working with human brain organoids and interested in longitudinal electrophysiology and drug testing.
✕Less likely to help
Patients are not directly enrolled; the work is a technological platform for future research.
What this research studies
This project aims to create an integrated platform that can record and stimulate brain organoids over extended periods without harming the organoids. It will include specialized 3D neural probes and a biological assay chamber designed for long-term health of organoids. The system will enable researchers to link electrical signals with molecular events over time, supporting better understanding of brain development and drug responses in a human-based model. The goal is to provide a turnkey solution that labs can use to run longitudinal electrophysiology assays in brain organoids. The work will be relevant to basic neuroscience and translational research in neurobiology and pharmacology.
Why it matters
Potential benefit: If successful, patients could benefit later from more predictive brain disease models and faster development of therapies.
How similar studies have gone: Preliminary work in organoid recording exists, but this integrated system for long-term, high-resolution, 3D electrophysiology is novel.
Where this research is happening
-
Neuronexus Technologies
Ann Arbor, United States Active
Researchers
- Principal investigator: Kipke, Daryl R — Neuronexus Technologies
- Study coordinator: Kipke, Daryl R
Related research
Other NIH-funded projects on the same topics.
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Developing a system to record brain activity in lab-grown brain organoids
This study is working on a new way to safely watch and understand how tiny brain models made from stem cells behave over time, which could help us learn more about brain function and find better treatments for brain-related conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.