Developing a system to record brain activity in lab-grown brain organoids
Official title: Advanced culture and recording system for long-term electrophysiological profiling in human brain organoids
Funded at Neuronexus Technologies · NIH-11069575 · Data updated 2026-11-12
This study is working on a new way to safely watch and understand how tiny brain models made from stem cells behave over time, which could help us learn more about brain function and find better treatments for brain-related conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neuronexus Technologies NIH-funded |
| Lab location | 1 site (Ann Arbor, UNITED STATES) |
| Project start | March 1, 2025 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $449,228 |
| NIH project number | 1R43MH139259-01 |
| Project ID | NIH-11069575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with neurological conditions or those interested in the underlying mechanisms of brain function may benefit from the advancements this research aims to achieve.
✕Less likely to help
Patients with conditions unrelated to neurological function or those not involved in research may not receive direct benefits from this research.
What this research studies
This research focuses on creating an advanced system that allows for long-term monitoring of electrical activity in brain organoids, which are miniaturized versions of the human brain grown from stem cells. By using innovative 3D neural probes and specialized assay chambers, the project aims to correlate the electrical signals of neurons with their molecular and cellular characteristics over extended periods. This could lead to significant advancements in understanding brain function and developing new treatments for neurological conditions. The system is designed to be non-destructive, allowing researchers to study brain organoids without harming them.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to breakthroughs in treating neurological disorders.
How similar studies have gone: Other research has shown promise in using organoid models for studying brain function, indicating that this approach could lead to significant advancements.
Where this research is happening
-
Neuronexus Technologies
Ann Arbor, United States Active
Researchers
- Principal investigator: Kipke, Daryl R — Neuronexus Technologies
- Study coordinator: Kipke, Daryl R
Related research
Other NIH-funded projects on the same topics.
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Advanced culture and recording system for long-term brain organoid activity
A new, user-friendly system will let researchers measure brain organoids’ electrical activity over weeks, helping scientists study how brain cells develop and respond to drugs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.