Developing a system to record brain activity in lab-grown brain organoids
Advanced culture and recording system for long-term electrophysiological profiling in human brain organoids
This study is working on a new way to safely watch and understand how tiny brain models made from stem cells behave over time, which could help us learn more about brain function and find better treatments for brain-related conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neuronexus Technologies NIH-funded |
| Lab location | 1 site (Ann Arbor, UNITED STATES) |
| Project ID | NIH-11069575 on NIH RePORTER |
What this research studies
This research focuses on creating an advanced system that allows for long-term monitoring of electrical activity in brain organoids, which are miniaturized versions of the human brain grown from stem cells. By using innovative 3D neural probes and specialized assay chambers, the project aims to correlate the electrical signals of neurons with their molecular and cellular characteristics over extended periods. This could lead to significant advancements in understanding brain function and developing new treatments for neurological conditions. The system is designed to be non-destructive, allowing researchers to study brain organoids without harming them.
Who could benefit from this research
Good fit: Patients with neurological conditions or those interested in the underlying mechanisms of brain function may benefit from the advancements this research aims to achieve.
Not a fit: Patients with conditions unrelated to neurological function or those not involved in research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and lead to breakthroughs in treating neurological disorders.
How similar studies have performed: Other research has shown promise in using organoid models for studying brain function, indicating that this approach could lead to significant advancements.
Where this research is happening
Ann Arbor, UNITED STATES
- Neuronexus Technologies — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kipke, Daryl R — Neuronexus Technologies
- Study coordinator: Kipke, Daryl R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.