Advanced changes in NOTCH3 and brain blood vessel disease
Official title: Advanced conformational changes in NOTCH3 and cerebrovascular disease severity
Funded at Veterans Health Administration · NIH-11458591 · Data updated 2026-11-12
Researchers are studying how changes in NOTCH3 contribute to brain blood vessel problems that worsen dementia in veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2017 |
| Project end | September 30, 2029 |
| Funding year | 2027 |
| NIH project number | 5I01BX003824-10 |
| Project ID | NIH-11458591 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with vascular brain disease, CADASIL, or other NOTCH3-related vascular cognitive impairment may be relevant for this research.
✕Less likely to help
Individuals without vascular brain disease or NOTCH3-related pathology may have little direct benefit.
What this research studies
This project looks at how specific alterations in the NOTCH3 protein affect brain blood vessels and how these changes relate to vascular cognitive impairment and dementia in people with vascular brain disease. Researchers will examine the sequence of NOTCH3 changes that occur with CADASIL and how they lead to the release of the NOTCH3 N-terminal fragment, seeking links to disease severity. The study builds on patient-derived observations and laboratory experiments to connect molecular changes with brain vascular damage and cognitive outcomes. Findings could point toward new targets for therapies that protect brain vessels and slow dementia progression.
Why it matters
Potential benefit: If successful, the work could identify molecular targets to develop treatments that protect brain blood vessels and slow dementia in affected individuals.
How similar studies have gone: Previous research has linked NOTCH3 alterations to CADASIL, and this project aims to extend those findings to broader vascular dementia contexts.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Wang, Michael M — Veterans Health Administration
- Study coordinator: Wang, Michael M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.