Administration and Data Center for Acute Graft‑Versus‑Host Disease
Admin Core: Administration, Biostatistics and Data Coordinating Center
This program organizes and analyzes transplant and GVHD medical data to help doctors improve care for people who receive bone marrow or stem cell transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11191467 on NIH RePORTER |
What this research studies
As a patient, this core collects and cleans clinical and biomarker information from thousands of transplant recipients to track acute GVHD outcomes. It maintains the MAGIC database, which includes about 5,000 hematopoietic cell transplant patients and 2,300 acute GVHD cases, and applies strict quality checks to minimize data errors. Biostatisticians provide study design, sample-size calculations, and analysis support for clinical and laboratory data, and the team helps plan and monitor clinical trials. The core also handles centralized data sharing, administrative oversight, and coordination across the program's projects to keep things organized and accountable.
Who could benefit from this research
Good fit: Ideal candidates are people who have had or will have hematopoietic cell (bone marrow or stem cell) transplants and those who develop or are at risk for acute GVHD and can share their medical records or samples.
Not a fit: People without a history of bone marrow/stem cell transplantation or with medical issues unrelated to GVHD are unlikely to receive direct benefits from this program.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection, better risk prediction, and improved treatment approaches for people with acute GVHD.
How similar studies have performed: Registry and database efforts like MAGIC and other transplant registries have already improved understanding of GVHD and clinical trial planning, so this builds on proven methods.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Ferrara, James L. M. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Ferrara, James L. M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.