Adjuvant Steroid Therapy for idiopathic subglottic stenosis in a multicenter randomized trial
Official title: 1/2 ASTRO: Adjuvant STeRoid Outcomes in idiopathic subglottic stenosis: A randomized trial
Funded at Johns Hopkins University · NIH-11621813 · Data updated 2026-11-12
A multicenter randomized trial will test whether injecting steroids into the narrow airway repeatedly can help people with idiopathic subglottic stenosis breathe better and reduce procedures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 15, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,642,535 |
| NIH project number | 4UH3HL173394-02 |
| Project ID | NIH-11621813 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adult women with idiopathic subglottic stenosis who are candidates for endoscopic dilation and may benefit from adjunctive intralesional steroids.
✕Less likely to help
Patients whose iSGS does not respond to steroid injections or who have contraindications to steroids may not experience benefit.
What this research studies
Idiopathic subglottic stenosis (iSGS) causes scar tissue that narrows the airway and makes breathing and speaking hard. This trial tests serial intralesional steroid injections as an adjunct to standard endoscopic dilation to see if it extends the time between procedures and improves breathing. It will be a prospective, randomized, double-blind, placebo-controlled study across multiple centers to identify which patients may benefit most. Results could guide how doctors manage iSGS and reduce the need for repeated interventions. The study is led by a team from Johns Hopkins and collaborators, with a clear focus on translating findings to patient care.
Why it matters
Potential benefit: If successful, patients could experience longer periods between dilations and better breathing, reducing procedures and improving quality of life.
How similar studies have gone: Earlier retrospective and prospective analyses suggested potential benefit, but results have been mixed, making this rigorous randomized trial important.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Hillel, Alexander — Johns Hopkins University
- Study coordinator: Hillel, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.