Adaptive immunity and AT1 receptor antibodies in preeclampsia and effects on offspring
Official title: Project II: Adaptive Immunity and AT1-AA in Mediating the PE Phenotype and Long-term Effects on Offspring
Funded at University of Mississippi Med Ctr · NIH-11397744 · Data updated 2026-11-12
A $201k, five-year study from the University of Mississippi Medical Center will explore how immune factors and AT1 receptor antibodies contribute to preeclampsia and its long-term effects on children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | August 15, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $201,405 |
| NIH project number | 5U54HL170290-02 |
| Project ID | NIH-11397744 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pregnant people with preeclampsia history or risk factors, and their offspring, may be eligible for related future studies or follow-up.
✕Less likely to help
Individuals without preeclampsia risk or a history of the condition may not directly benefit from this particular research.
What this research studies
This project looks at how immune system signals, including TNF-α and AT1-AA antibodies, contribute to preeclampsia in pregnant people and how these factors may affect their children later in life. Researchers will use animal models and human samples to study placental and brain changes, high blood pressure, and cognitive outcomes related to exposure during pregnancy. The work aims to identify key immune players and test interventions that could blunt harmful effects, potentially reducing risk for mothers and offspring. Results could inform future therapies or preventive strategies for families affected by preeclampsia and related immune changes.
Why it matters
Potential benefit: If successful, the study could lead to new ways to prevent or lessen the impact of preeclampsia on mothers and their children.
How similar studies have gone: Previous work in animals and some human data show immune mediators influence preeclampsia and offspring outcomes; this project seeks to expand on those findings in a translational way.
Where this research is happening
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University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Lamarca, Babbette — University of Mississippi Med Ctr
- Study coordinator: Lamarca, Babbette
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.