Acquiring advanced technology for studying complex proteins
Official title: Acquisition of a dedicated and integrated HD-MS instrument
Funded at Case Western Reserve University · NIH-11100513 · Data updated 2026-11-12
This study is working to get a new, advanced machine that will help scientists better understand how proteins behave in diseases like Alzheimer's and other complex conditions, making their research more accurate and efficient.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 15, 2025 |
| Project end | April 14, 2026 |
| Funding year | 2025 |
| Award (this year) | $750,000 |
| NIH project number | 1S10OD036418-01A1 |
| Project ID | NIH-11100513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals under 15 years of age with conditions related to abnormal protein folding or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or those over the age of 15 may not receive direct benefits from this research.
What this research studies
This research aims to obtain a cutting-edge mass spectrometry system that will enhance the study of complex protein structures, particularly those related to various diseases. The new equipment will replace outdated technology, allowing researchers to conduct more efficient and reliable experiments on protein interactions and abnormalities. By focusing on hydrogen/deuterium exchange studies, this project will support a wide range of biomedical research efforts at Case Western Reserve University and affiliated institutions. This technology is crucial for understanding protein behavior in conditions like neurodegenerative disorders and other complex diseases.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding and treating diseases associated with protein misfolding and aggregation.
How similar studies have gone: Other research utilizing advanced mass spectrometry techniques has shown promise in understanding complex biological systems, indicating that this approach is likely to yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Miyagi, Masaru — Case Western Reserve University
- Study coordinator: Miyagi, Masaru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.