Accelerated aging in the brain with HIV/SIV infection
Official title: Accelerated aging in the CNS of SIV-infected macaques
Funded at Tulane University of Louisiana · NIH-11470836 · Data updated 2026-11-12
This grant studies how HIV-related brain aging happens in a macaque model to better understand why people living with HIV may experience cognitive problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $871,998 |
| NIH project number | 1R01AG099750-01A1 |
| Project ID | NIH-11470836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal for future translational work where people with HIV may benefit from interventions targeting brain aging and inflammation.
✕Less likely to help
Results may be less directly applicable to individuals without HIV or aging-related brain changes.
What this research studies
Researchers will use SIV-infected macaques to explore how brain support cells called astrocytes contribute to aging and inflammation in the brain. The study looks at how these cells respond to HIV-related proteins over time and how this affects the blood-brain barrier and brain regions tied to thinking and memory. The goal is to identify mechanisms that drive accelerated aging in the brain and to point to targets for therapies that could protect cognitive function in people with HIV. Findings from this non-human primate model could inform future human studies and guide strategies to prevent or lessen neurocognitive decline in ART-treated patients.
Why it matters
Potential benefit: If successful, this work could reveal new targets to protect the aging brain in people living with HIV and guide future clinical research.
How similar studies have gone: Previous studies in similar models have linked glial activation to accelerated aging; this project builds on that foundation with a focused mechanism in astrocytes.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Maclean, Andrew G — Tulane University of Louisiana
- Study coordinator: Maclean, Andrew G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.