A registry for understanding severe chronic neutropenia and its treatments
Official title: Severe Chronic Neutropenia International Registry
Funded at Boston Children's Hospital · NIH-10897770 · Data updated 2026-11-12
This study is all about helping people with severe chronic neutropenia (SCN) by gathering information from patients to learn more about the condition and find better treatments, so your experiences can make a difference in future care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 25, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,122,390 |
| NIH project number | 5R24AI162637-03 |
| Project ID | NIH-10897770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with severe chronic neutropenia, regardless of whether their condition is congenital or acquired.
✕Less likely to help
Patients without a diagnosis of severe chronic neutropenia or those who do not experience significant infections related to neutropenia may not benefit from this research.
What this research studies
This research focuses on severe chronic neutropenia (SCN), a condition that significantly increases the risk of life-threatening infections due to low levels of neutrophils, a type of white blood cell. The Severe Chronic Neutropenia International Registry (SCNIR) collects and analyzes data from patients with SCN to better understand the disease's natural history, treatment responses, and long-term outcomes. By leveraging advancements in database science and molecular biology, the research aims to discover new treatments and improve medical management for those affected by SCN. Patients can contribute their experiences and outcomes, which will help shape future therapies and clinical guidelines.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management strategies for patients with severe chronic neutropenia.
How similar studies have gone: Previous research utilizing registries and collaborative data collection has shown success in advancing understanding and treatment of similar immunodeficiencies.
Where this research is happening
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Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Shimamura, Akiko — Boston Children's Hospital
- Study coordinator: Shimamura, Akiko
Related research
Other NIH-funded projects on the same topics.
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Severe Chronic Neutropenia Registry for Patients
A patient-facing registry that tracks severe chronic low neutrophil counts to improve understanding and care for people with this condition.
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Severe Chronic Neutropenia Registry to Improve Care
A patient-focused registry gathers information from adults with severe chronic neutropenia to better understand infections, treatments, and outcomes over time.
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Severe Chronic Neutropenia Registry: Finding Better Ways to Prevent Infections
A patient-focused registry at a leading hospital helps people with severe chronic neutropenia learn how the condition progresses and how treatments work over time.
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Stimulant that grows donor stem cells in the body to speed neutropenia recovery after chemotherapy and stem cell transplant
A drug given during or right before stem cell transplant helps donor stem cells multiply quickly inside the patient to shorten neutropenia after treatment.
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Stimulant to grow stem cells in the body to speed recovery after chemotherapy and stem cell transplant
A new drug given briefly before transplant aims to help patients recover their blood and immune system faster after chemotherapy or stem cell transplant.
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PointCheck: a home-based, non-invasive neutropenia monitor for chemotherapy patients
A portable, non-invasive device helps cancer patients on chemotherapy monitor neutropenia from home so doctors can prevent serious infections.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.