A platform to study gene regulation in immune diseases and COVID-19.
iSCREEN: An Integrative Data and Annotation Platform of Gene Regulation for Immune-mediated Disease Research
This study is looking at how our genes influence immune-related diseases like COVID-19, using advanced technology to better understand how certain parts of our DNA work, which could help doctors find more personalized treatments for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10873829 on NIH RePORTER |
What this research studies
This research focuses on creating an integrative data platform that utilizes advanced genomic techniques to explore how gene regulation affects immune-mediated diseases, including COVID-19. By employing deep-sequencing methods and machine learning, the project aims to analyze non-coding regulatory elements, such as enhancers, that play a crucial role in immune responses. The goal is to develop an atlas of these regulatory elements to enhance our understanding of disease mechanisms and improve precision medicine approaches for treatment and prognosis. Patients may benefit from insights gained about their specific immune responses and potential treatment pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune diseases, COVID-19, or other immune-related conditions.
Not a fit: Patients with non-immune-related conditions or those not affected by autoimmune diseases may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with immune-mediated diseases and COVID-19.
How similar studies have performed: Other research has shown success in using genomic approaches to understand immune responses, indicating that this methodology has potential for impactful findings.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Weng, Zhiping — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Weng, Zhiping
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.