A new system to study how fungal infections spread in the bloodstream
Under-oil open microfluidic system (UOMS) for studying systemic fungal infection
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11007188
This study is looking at how a type of yeast called Candida can cause serious infections in people with catheters, and it’s testing a new way to mimic the body’s conditions to find better treatments for these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11007188 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how Candida, a type of yeast, causes serious bloodstream infections, particularly in patients with catheters. It aims to develop an innovative under-oil open microfluidic system (UOMS) that can simulate the conditions in the body to study how yeast cells disperse from biofilms into the bloodstream. By quantifying this dispersion and analyzing the characteristics of the dispersed cells, the research seeks to identify new treatment targets that could improve patient outcomes. The approach leverages a novel phenomenon called Exclusive Liquid Repellency (ELR) to create a unique testing environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with catheter-associated Candida infections or those at high risk for such infections.
Not a fit: Patients with non-fungal infections or those not using catheters may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for patients suffering from severe fungal infections, potentially reducing mortality rates.
How similar studies have performed: While research on fungal infections is ongoing, this specific approach using the UOMS is novel and has not been extensively tested in previous studies.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEEBE, DAVID J — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BEEBE, DAVID J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections, blood infection