A new MRI contrast agent for heart imaging
Manganese-based MRI contrast agent for quantitative myocardial perfusion imaging
This study is testing a new MRI contrast agent called MnBP to see if it can help doctors get clearer and more accurate images of heart blood flow in patients with coronary artery disease, especially those with complicated cases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Laderx LLC NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10933982 on NIH RePORTER |
What this research studies
This research focuses on developing a manganese-based contrast agent for MRI that aims to improve the accuracy of myocardial perfusion imaging (MPI) in patients with coronary artery disease. Current imaging techniques often fall short in assessing complex cases, particularly those with multiple vessel diseases. The new agent, MnBP, is designed to provide quantitative data alongside high-resolution anatomical images, which could lead to better diagnosis and management of heart conditions. The study will involve administering this agent to patients to evaluate its effectiveness compared to existing methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with known or suspected coronary artery disease, especially those with complex conditions like multivessel disease.
Not a fit: Patients without coronary artery disease or those who are not undergoing myocardial perfusion imaging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and improved treatment strategies for patients with coronary artery disease.
How similar studies have performed: While MRI techniques have been used before, the specific use of manganese-based contrast agents for quantitative MPI is a novel approach that has shown promising preliminary results in animal studies.
Where this research is happening
Durham, United States
- Laderx LLC — Durham, United States (Active)
Researchers
- Principal investigator: Song, Allen W — Laderx LLC
- Study coordinator: Song, Allen W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.