A new method to improve bladder function using a special scaffold
A Biomechanocompatible Small Molecule Releasing Scaffold for Bladder Augmentation
['FUNDING_R01'] · LURIE CHILDREN'S HOSPITAL OF CHICAGO · NIH-11048585
This study is testing a new way to help people with bladder problems by using a special scaffold that releases helpful molecules to grow new bladder tissue, aiming to improve bladder function without the risks of traditional surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LURIE CHILDREN'S HOSPITAL OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11048585 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel scaffold that releases small molecules to enhance bladder augmentation for patients with pathologic bladders. The approach aims to regenerate bladder tissue without the complications associated with traditional surgical methods, such as using bowel patches. By utilizing bone marrow stem/progenitor cells, the research seeks to overcome existing barriers in bladder tissue regeneration, including nerve regeneration and vascularization. Patients may benefit from improved bladder function and reduced complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from chronic bladder conditions that lead to urinary incontinence and potential renal failure.
Not a fit: Patients with non-pathologic bladder conditions or those who do not require bladder augmentation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for bladder augmentation, improving quality of life for patients with bladder dysfunction.
How similar studies have performed: While there have been attempts at bladder tissue regeneration, this specific approach using a biomechanocompatible scaffold is novel and has not been extensively tested in clinical settings.
Where this research is happening
CHICAGO, UNITED STATES
- LURIE CHILDREN'S HOSPITAL OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHARMA, ARUN — LURIE CHILDREN'S HOSPITAL OF CHICAGO
- Study coordinator: SHARMA, ARUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute kidney injury