A new method for quickly isolating tiny vesicles from body fluids for disease diagnosis
Official title: Magnetic Lipid Nanoprobe Platform for Rapid, Highly-Efficient, and Cost-Effective Isolation of Extracellular Vesicles from Non-Invasive Bodily Fluids
Funded at Captis Diagnostics · NIH-11077464 · Data updated 2026-11-12
This study is testing a new way to quickly and easily collect tiny particles from your blood, saliva, or urine that can help doctors spot diseases like cancer and heart problems without needing to do painful tissue samples.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Captis Diagnostics NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | March 11, 2025 |
| Project end | March 10, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,077,369 |
| NIH project number | 1R44TR005339-01A1 |
| Project ID | NIH-11077464 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions such as cancer, cardiovascular diseases, or those requiring frequent monitoring without invasive procedures.
✕Less likely to help
Patients who do not have access to the required bodily fluids or those with conditions that do not involve extracellular vesicles may not benefit from this research.
What this research studies
This research focuses on developing a novel lipid nanoprobe platform that allows for the rapid and efficient isolation of extracellular vesicles (EVs) from various non-invasive bodily fluids such as blood, saliva, and urine. These EVs serve as biomarkers for a range of diseases, including cancers and cardiovascular conditions, and can provide critical information without the need for invasive tissue biopsies. The approach aims to streamline the process of EV isolation, making it more accessible and cost-effective for clinical use. By utilizing this innovative technology, the research seeks to enhance molecular diagnostics through a multi-omics approach, which includes genomics and proteomics.
Why it matters
Potential benefit: If successful, this research could significantly improve disease diagnosis and monitoring by providing a less invasive method to obtain critical biological information.
How similar studies have gone: Other research has shown promise in using extracellular vesicles as biomarkers, indicating that this approach has potential for success in clinical applications.
Where this research is happening
-
Captis Diagnostics
Pittsburgh, United States Active
Researchers
- Principal investigator: He, Hongzhang — Captis Diagnostics
- Study coordinator: He, Hongzhang
Related research
Other NIH-funded projects on the same topics.
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This study is working on a new way to quickly and easily collect tiny particles from your blood that can help doctors find signs of brain diseases like Alzheimer's and ALS, making it easier to check your brain health without needing invasive tests.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.