A device to diagnose and monitor acute respiratory distress syndrome using breath analysis
Official title: Point-of-care micro-gas chromatography device for diagnosis and monitoring of acute respiratory distress syndrome using exhaled breath signatures
Funded at University of Michigan at Ann Arbor · NIH-11004101 · Data updated 2026-11-12
This study is testing a small, portable device that can analyze your breath to help doctors diagnose and keep track of acute respiratory distress syndrome (ARDS) by looking for specific chemicals in your breath.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $962,808 |
| NIH project number | 5R01HL171517-02 |
| Project ID | NIH-11004101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing acute respiratory distress or related conditions.
✕Less likely to help
Patients with chronic respiratory conditions or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing a portable micro-gas chromatography device that can analyze exhaled breath to diagnose and monitor acute respiratory distress syndrome (ARDS). By capturing volatile organic compounds (VOCs) and inorganic compounds (VICs) from the breath, the device aims to identify specific patterns that indicate the presence of ARDS and track its progression over time. The research involves validating initial findings from a small group of patients and gathering extensive data to refine the device's accuracy and effectiveness in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to a non-invasive method for early diagnosis and continuous monitoring of ARDS, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using breath analysis for diagnosing respiratory conditions, suggesting that this approach could be effective.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Fan, Xudong — University of Michigan at Ann Arbor
- Study coordinator: Fan, Xudong
Related research
Other NIH-funded projects on the same topics.
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This grant aims to help doctors figure out which adults with ARDS are most likely to benefit from paralytic medications using detailed bedside data and electronic health records.
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Resilience endotypes and early ARDS detection using biomarkers and AI
A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
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This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.