How NHERF1 controls MRGPRX2 signals in mast cells
Official title: NHERF1 regulates MRGPRX2/MrgprB2 responses in mast cells
Funded at Michigan State University · NIH-11360116 · Data updated 2026-11-12
This project studies a key protein regulator (NHERF1) that affects how mast cells react through a pain-free pathway linked to allergies and skin and airway diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | July 12, 2023 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $475,479 |
| NIH project number | 5R01AI177305-03 |
| Project ID | NIH-11360116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with allergic diseases or mast cell–related conditions who may benefit from safer drug responses could participate in future related trials or samples studies.
✕Less likely to help
People without allergic disease or those not related to mast cell–drug reactions may not benefit from this project.
What this research studies
If successful, the work will clarify how NHERF1 influences mast cell responses triggered by MRGPRX2 in human cells and a mouse model. Researchers will use a new mouse strain, human stem cell–derived mast cells, and humanized mice to explore the signaling steps leading to degranulation and inflammatory reactions. The findings could reveal new targets to reduce pseudoallergic reactions and improve treatments for conditions like rosacea, urticaria, and asthma. The study aims to translate basic mechanisms into approaches that may lessen severe allergic responses in people who react to certain FDA-approved drugs.
Why it matters
Potential benefit: Understanding NHERF1’s role could lead to new strategies to prevent or lessen dangerous allergic reactions and inflammatory symptoms.
How similar studies have gone: Previous data show NHERF1 regulates MRGPRX2 responses in mast cells, supporting potential translation to human therapies.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Laumet, Geoffroy O — Michigan State University
- Study coordinator: Laumet, Geoffroy O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.