Understanding the Genetic Roots of Male Infertility
Official title: Genomics of spermatogenic impairment
Funded at Oregon Health & Science University · NIH-11133006 · Data updated 2026-11-12
This research helps us understand the genetic reasons why some men experience severe infertility, aiming to improve diagnosis and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 10, 2014 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $616,402 |
| NIH project number | 5R01HD078641-10 |
| Project ID | NIH-11133006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Men experiencing severe male infertility, particularly those with nonobstructive azoospermia, would be the focus of this research.
✕Less likely to help
Patients whose infertility is not related to genetic factors or who are not male would not directly benefit from this specific genetic research.
What this research studies
Our team is working to uncover the specific genetic changes that lead to severe male infertility, especially a condition called nonobstructive azoospermia. We partner with doctors and use advanced computer tools to find new genetic causes. By understanding these genetic links, we hope to offer better ways to diagnose and treat infertility. This work also explores how male infertility might be connected to other health issues like cancer and heart disease.
Why it matters
Potential benefit: If successful, this work could lead to more accurate diagnoses and new treatment options for men with genetic forms of infertility, and provide insights into their broader health risks.
How similar studies have gone: This project builds on previous successful efforts that have already identified many new genetic causes for male infertility.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Conrad, Donald F. — Oregon Health & Science University
- Study coordinator: Conrad, Donald F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.