Understanding and improving treatments for urethral stricture disease in men
Official title: Repeated Transurethral Interventions and Progressive Urethral Stricture Disease: Elucidation of Mechanisms and Novel Interventional Strategies
Funded at VA San Diego Healthcare System · NIH-10975939 · Data updated 2026-11-12
This study is looking into why urethral stricture disease happens in men and how repeated treatments without surgery might cause more scarring, with the goal of finding better ways to prevent or manage the condition, so patients can have access to new and improved therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX002401-03 |
| Project ID | NIH-10975939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men suffering from urethral stricture disease, particularly those who have undergone multiple non-surgical interventions.
✕Less likely to help
Patients with urethral stricture disease who have not undergone any interventions or those with other unrelated urinary conditions may not benefit from this research.
What this research studies
This research investigates the causes and effects of urethral stricture disease (USD) in men, particularly focusing on how repeated non-surgical interventions can lead to increased scarring and complications. The study aims to analyze the molecular mechanisms behind this scarring, including the role of urinary microbiomes and fibrosis. By understanding these processes, the research seeks to identify new treatment strategies that could prevent or better manage USD. Patients may benefit from innovative therapies that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for urethral stricture disease, improving urinary function and quality of life for affected patients.
How similar studies have gone: Previous research has shown that understanding the molecular mechanisms of tissue scarring can lead to successful treatment innovations, suggesting potential for success in this study.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Rajasekaran, Mahadevan Raj — VA San Diego Healthcare System
- Study coordinator: Rajasekaran, Mahadevan Raj
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.