Drug or treatment

Tofacitinib clinical trials

• 17Clinical trials
• 1New in 30 days
• 7Countries

Newest trials

All recruiting trials (17)

• Tislelizumab with Tofacitinib and Docetaxel for NSCLC After First-Line Immunotherapy

  This study tests whether adding tofacitinib to tislelizumab and docetaxel helps people with locally advanced or metastatic NSCLC who did not respond to first-line immunotherapy.

  Recruiting Phase 2 Anhui Provincial Hospital · Hefei, Anhui · NCT07925866

• Safety and drug level study of multiple doses of upadacitinib, tofacitinib, and baricitinib in healthy adults

  This early-phase study tests how different doses of upadacitinib, tofacitinib, and baricitinib behave in healthy adults to understand safety and how the drugs act in the body.

  Recruiting Phase 1 AbbVie · Grayslake, Illinois · NCT07843693

• Heart event risk in people with moderate-to-severe rheumatoid arthritis taking tofacitinib plus a statin versus TNF inhibitors.

  This will test whether taking tofacitinib with a daily statin changes the rate of major heart problems in people 50 and older with moderate-to-severe rheumatoid arthritis and at least one cardiovascular risk factor.

  Recruiting Phase 4 Shaikh Zayed Hospital, Lahore · Lahore, Punjab Province · NCT07554820

• Tofacitinib for steroid‑resistant moderate-to-severe thyroid eye disease

  This will test whether taking oral tofacitinib (5 mg twice daily) for 24 weeks can reduce eye bulging and inflammation in adults with moderate-to-severe thyroid eye disease who don't respond to or cannot take high-dose steroids.

  Recruiting Phase 2 The First Affiliated Hospital of Xiamen University · Xiamen, Fujian · NCT07547930

• Topical anti-inflammatory plus yellow light with tofacitinib and doxycycline for mild to moderate erythematotelangiectatic rosacea

  This trial will try combining a topical anti-inflammatory regimen (Hirudoid followed by yellow light therapy) with the oral medicines tofacitinib and doxycycline to see if it helps Chinese adults with mild to moderate erythematotelangiectatic rosacea.

  Recruiting The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT07343635

• Tofacitinib safety for people with primary Sjogren disease

  This study will test whether the oral pill tofacitinib is safe and tolerable for adults with primary Sjogren disease and mild-to-moderate symptoms.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07281456

• Oral methotrexate versus tofacitinib for chronic plaque psoriasis

  This trial will test whether oral methotrexate or tofacitinib works better for adults with moderate-to-severe chronic plaque psoriasis.

  Recruiting Early Phase 1 Lahore General Hospital · Lahore, Punjab Province · NCT07261306

• Tofacitinib in Juvenile Idiopathic Arthritis

  This study looks at real-world use of tofacitinib to see if it helps control Juvenile Idiopathic Arthritis in kids over about 12 months.

  Recruiting at 7 sites Consorci Sanitari de l'Alt Penedès i Garraf · A Coruña, A Coruña and 6 other locations · NCT07211932

• Adding oral tofacitinib to topical steroid ointment for moderate-to-severe oral lichen planus

  This study will test whether taking oral tofacitinib along with standard topical triamcinolone helps adults with moderate-to-severe oral lichen planus get better than steroid ointment alone.

  Recruiting Phase 4 All India Institute of Medical Sciences, Bhubaneswar · Bhubaneswar, Odisha · NCT07131813

• Tofacitinib plus acitretin versus acitretin alone for primary cutaneous amyloidosis

  This tests whether adding tofacitinib to acitretin helps adults with primary cutaneous amyloidosis and relieves itch faster than acitretin alone.

  Recruiting Phase 4 Army Medical University, China · Chongqing, Chongqing Municipality · NCT06998875

• Combining telitacicept and tofacitinib for treating difficult rheumatoid arthritis

  This study tests if combining two medications, telitacicept and tofacitinib, can help adults with tough-to-treat rheumatoid arthritis feel better when other treatments haven't worked.

  Recruiting Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06979271

• Comparing secukinumab and tofacitinib for treating hidradenitis suppurativa in Chinese patients

  This study is testing whether secukinumab or tofacitinib works better for treating moderate to severe hidradenitis suppurativa in Chinese adults.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06707246

• Tofacitinib cream for treating early-stage Cutaneous T-cell Lymphoma

  This study is testing if a new cream can help people with early-stage Cutaneous T-cell Lymphoma feel better and improve their skin after 12 weeks of treatment.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06698822

• Methotrexate plus tofacitinib for rheumatoid arthritis

  This project will test whether adding tofacitinib to methotrexate helps adults with early, moderate-to-severe rheumatoid arthritis who have a myeloid-stromal synovial pattern.

  Recruiting at 5 sites Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Foshan, Guangdong and 4 other locations · NCT06301373

• Evaluating tofacitinib for early active axial spondyloarthritis

  This study is testing if a medication called tofacitinib can help people with early active axial spondyloarthritis who haven't found relief from traditional pain relievers.

  Recruiting Phase 4 Charite University, Berlin, Germany · Berlin · NCT06112665

• Combining tocilizumab and tofacitinib for treating vascular Behçet's syndrome

  This study is testing if combining two newer medications, tocilizumab and tofacitinib, with steroids can help people with vascular Behçet's syndrome feel better compared to the usual treatment.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05845723

• Effects of Ulcerative Colitis Treatments on Heart Health

  This study is testing how different treatments for ulcerative colitis might affect heart health over time.

  Recruiting Phase 4 Centre Hospitalier Universitaire, Amiens · Amiens · NCT04743518

Quick answers

How many clinical trials of Tofacitinib are recruiting right now?

17, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (8 trials), United States (3 trials), Pakistan (2 trials), France (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 5, Phase 2: 5, Early Phase 1: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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