Condition
TP53 Gene Mutation clinical trials and research
As of November 12, 2026, Find a Trial lists 3 TP53 Gene Mutation clinical trials that are recruiting, at sites in 3 countries (most in Italy (1), United States (1), Hong Kong (1)). By phase: Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 3Clinical trials
- 3Countries
Newest TP53 Gene Mutation clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Germline TP53 gene testing in patients seen at the IEO | — | Milan | Recruiting | Feb 19, 2026 |
| Oral arsenic trioxide plus vitamin C with low-intensity therapy for TP53-mutated AML/MDS/CMML | Phase 2 | Hong Kong | Recruiting | Jan 16, 2025 |
| Understanding Li-Fraumeni Syndrome and TP53 Variants | — | Boston, Massachusetts and 2 other locations | Recruiting | Sep 9, 2020 |
All recruiting trials (3)
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Germline TP53 gene testing in patients seen at the IEO
This project looks at past genetic test results to see how often harmful TP53 changes were found in people who had counseling and germline TP53 testing at the IEO between 2004 and 2025.
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Oral arsenic trioxide plus vitamin C with low-intensity therapy for TP53-mutated AML/MDS/CMML
This trial will test whether taking oral arsenic trioxide with vitamin C plus a low-intensity drug (a hypomethylating agent, with or without venetoclax) helps adults with TP53-mutated AML, MDS, or CMML who are newly diagnosed or have relapsed/refractory disease.
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Understanding Li-Fraumeni Syndrome and TP53 Variants
This study is trying to understand cancer risks in people with Li-Fraumeni Syndrome or TP53 gene changes to help improve prevention and treatment options.
Related topics
Quick answers
How many TP53 Gene Mutation clinical trials are recruiting right now?
3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in Italy (1 trial), United States (1 trial), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.