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Refractory Acute Lymphoblastic Leukemia clinical trials and research

• 14Clinical trials
• 2Countries

Newest Refractory Acute Lymphoblastic Leukemia clinical trials

All recruiting trials (14)

• Nanobody CD5 CAR‑T for relapsed or refractory CD5‑positive T‑cell cancers

  This will test a CD5-targeted CAR‑T cell treatment using patients' own or donor-derived cells to try to help people with relapsed or refractory CD5+ T‑cell leukemias and lymphomas.

  Recruiting at 3 sites Phase 1/2 Beijing GoBroad Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07070323

• CAR T cell therapy for young patients with CD19-positive leukemia

  This study is testing a new treatment combining CAR T cell therapy and chemotherapy to see if it helps young patients with hard-to-treat leukemia.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06847269

• Evaluating CAR-T cell therapy with or without stem cell transplantation for relapsed B-cell leukemia

  This study tests if adding a stem cell transplant after CAR-T cell therapy can help young people with relapsed B-cell leukemia live longer and feel better.

  Recruiting Peking University People's Hospital · Beijing, Beijing Municipality · NCT06581081

• CD5 CAR T-cell therapy for relapsed or refractory T-cell malignancies

  This study is testing a new CAR T-cell therapy for people with hard-to-treat T-cell cancers to see if it is safe and how well it works.

  Recruiting at 3 sites Phase 1/2 Beijing GoBroad Hospital · Beijing, Beijing Municipality and 3 other locations · NCT06316856

• CD7 CAR-T therapy for patients with relapsed or refractory T-cell malignancies

  This study is testing a new type of CAR-T therapy for people with T-cell leukemia that hasn't responded to other treatments to see if it can help them feel better.

  Recruiting at 3 sites Phase 1/2 Beijing GoBroad Hospital · Beijing, Beijing Municipality and 3 other locations · NCT06316427

• Treatment for Acute Lymphoblastic Leukemia using modified T cells

  This study is testing a new treatment using specially modified T cells to see if it can help people with Acute Lymphoblastic Leukemia who haven't had success with other therapies.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06287528

• Genetically engineered CAR T-cells for treating certain blood cancers

  This study is testing a new type of treatment using specially modified immune cells to see if they can help people with certain blood cancers that haven't responded to other treatments.

  Recruiting at 2 sites Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio and 1 other locations · NCT05418088

• Treatment of relapsed or refractory B-ALL in children and adolescents using pCAR-19B

  This study is testing a new CAR T-cell therapy called pCAR-19B to see if it can help children and teens with hard-to-treat B-cell leukemia feel better.

  Recruiting at 16 sites Phase 2 Chongqing Precision Biotech Co., Ltd · Beijing, Beijing Municipality and 15 other locations · NCT05334823

• Using a radioactive antibody followed by stem cell transplant to treat high-risk leukemia or myelodysplastic syndrome

  This study is testing a new radioactive treatment combined with a stem cell transplant to see if it can help people with high-risk leukemia or myelodysplastic syndrome feel better and improve their chances of recovery.

  Recruiting Phase 1/2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03670966

• HA-1 TCR T cell therapy for leukemia that returned or didn't respond after a donor stem cell transplant

  This Phase 1 study will test whether giving specially engineered donor T cells called HA-1 TCR T cells is safe and what dose works for people whose acute leukemia came back or didn't respond after a donor stem cell transplant.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03326921

• Combining blinatumomab, methotrexate, cytarabine, and ponatinib for treating certain types of leukemia

  This study is testing a new combination of four medications to see if it can help people with certain types of leukemia that have come back or didn't respond to previous treatments.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT03263572

• Combination chemotherapy for relapsed or refractory acute lymphoblastic leukemia and related conditions

  This study is testing a new combination of chemotherapy drugs to see if it can help people with relapsed or hard-to-treat acute lymphoblastic leukemia and related blood cancers feel better and live longer.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT03136146

• Using radioactive treatment before stem cell transplant for high-risk leukemia patients

  This study is testing a new radioactive treatment given before a stem cell transplant to see if it can help high-risk leukemia patients by targeting cancer cells while protecting healthy ones.

  Recruiting Phase 1/2 Fred Hutchinson Cancer Center · Seattle, Washington · NCT03128034

• Personalized NK cell therapy after umbilical cord blood transplant for leukemia

  This study is testing if a special treatment using personalized immune cells from umbilical cord blood can help people with leukemia feel better after their transplant.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT02727803

Related topics

Quick answers

How many Refractory Acute Lymphoblastic Leukemia clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (9 trials), China (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1/2: 5, Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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