Condition

Premature Ovarian Insufficiency clinical trials and research

• 10Clinical trials
• 1New in 30 days
• 5Countries

Newest Premature Ovarian Insufficiency clinical trials

All recruiting trials (10)

• Autologous Hair Follicle Secretome + PRP for POI

  This pilot study tests whether a patient’s own hair follicle secretome combined with their own platelet-rich plasma can improve ovarian function in women with premature ovarian insufficiency.

  Recruiting Phase 2 Trio Fertility · Toronto, Ontario · NCT07916740

• Intravenous hUC-MSCs for POI: Safety, Tolerability and Early Efficacy

  We’re testing whether IV human umbilical cord mesenchymal stem cells can be safely given to women under 40 with premature ovarian insufficiency to see if it helps improve ovarian function.

  Recruiting Phase 1/2 Shenzhen Wingor Biotechnology Co., Ltd. · Beijing, Beijing Municipality · NCT07775391

• Human amniotic mesenchymal stem cell treatment for premature ovarian insufficiency

  This trial will test whether an intravenous infusion of human amniotic mesenchymal stem cells combined with standard hormone therapy can help women under 40 with premature ovarian insufficiency.

  Recruiting Phase 1/2 Changhai Hospital · Shanghai · NCT07115082

• Hormone replacement for adolescents with premature ovarian insufficiency

  This study will test estrogen patches plus progesterone in girls and young women aged 11–19 with premature ovarian insufficiency to see if hormone replacement improves bone density, metabolic markers, muscle strength, and cardiovascular health.

  Recruiting Phase 3 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06851754

• Using Platelet-rich Plasma to Improve Female Fertility

  This study is testing whether injections of platelet-rich plasma can help improve fertility in women dealing with issues like poor ovarian response and repeated implantation failure.

  Recruiting The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang · NCT06645379

• Using fat-derived cells to treat premature ovarian insufficiency

  This study is testing if using fat-derived cells can help improve pregnancy chances for women with premature ovarian insufficiency compared to standard IVF treatments.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality · NCT06481969

• Examining the link between ovarian function and serum biomarkers

  This study is trying to see how blood markers differ between healthy women and those with ovarian issues to better understand their connection.

  Recruiting Dongzhimen Hospital, Beijing · Beijing · NCT06096766

• Understanding Premature Ovarian Insufficiency: Observations from Multiple Hospitals

  This study tests how POI develops and affects health by tracking women with POI across several centers.

  Recruiting Women's Hospital School Of Medicine Zhejiang University · Hangzhou, Zhejiang and 1 other locations · NCT06067529

• Assessing the role of Anti-Müllerian hormone in women's reproductive health

  This study is testing if measuring a hormone called Anti-Müllerian hormone (AMH) can help women with conditions like polycystic ovarian syndrome and premature ovarian insufficiency, and improve their chances of success with fertility treatments.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT05858307

• Effects of hormone replacement therapy on heart function in women with premature ovarian insufficiency

  This study tests how hormone replacement therapy affects heart function in women under 40 with premature ovarian insufficiency to see if it changes their heart rhythm.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Bordeaux and 2 other locations · NCT04167033

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Quick answers

How many Premature Ovarian Insufficiency clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in China (6 trials), United States (1 trial), France (1 trial), Hong Kong (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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