Condition

Moderate to Severe Atopic Dermatitis clinical trials and research

• 10Clinical trials
• 13Countries

Newest Moderate to Severe Atopic Dermatitis clinical trials

All recruiting trials (10)

• A Phase 3 test of Rezpegaldesleukin (NKTR-358) for moderate-to-severe atopic dermatitis in patients 12 years and older

  This Phase 3 study tests whether Rezpegaldesleukin helps people aged 12 and up with moderate-to-severe atopic dermatitis compared to placebo.

  Recruiting at 13 sites Phase 3 Nektar Therapeutics · Birmingham, Alabama and 12 other locations · NCT07711418

• Rezpegaldesleukin for moderate-to-severe atopic dermatitis in people 12 and older

  This study tests whether Rezpegaldesleukin helps people aged 12 and up with moderate-to-severe atopic dermatitis compared with a placebo.

  Recruiting at 20 sites Phase 3 Nektar Therapeutics · Phoenix, Arizona and 19 other locations · NCT07690371

• Nemolizumab for infants with moderate-to-severe atopic dermatitis

  This study tests whether nemolizumab can be safely given to infants aged 6 to under 24 months to help manage moderate-to-severe eczema when topical treatments alone aren’t enough.

  Recruiting Phase 2 Galderma R&D · San Antonio, Texas · NCT07660835

• SYX-5219 in healthy adults and adults with moderate-to-severe atopic dermatitis

  This trial will test oral SYX-5219 in healthy adults and in adults with moderate-to-severe atopic dermatitis to see if it is safe, well tolerated, and how the drug is processed in the body.

  Recruiting at 12 sites Phase 1 Sitryx Therapeutics Ltd · Arkansas City, Arkansas and 13 other locations · NCT07558668

• Oral LW402 for moderate-to-severe atopic dermatitis

  This phase 3 study tests whether oral LW402 tablets can help adults with moderate-to-severe atopic dermatitis compared with a placebo.

  Recruiting Phase 3 Shanghai Longwood Biopharmaceuticals Co., Ltd. · Beijing · NCT07370909

• SHR-1905 treatment for moderate-to-severe atopic dermatitis

  This trial will test whether SHR-1905 injections help adults aged 18–75 who have moderate-to-severe atopic dermatitis.

  Recruiting Phase 2 Guangdong Hengrui Pharmaceutical Co., Ltd · Guangzhou, Guangdong · NCT07211542

• TRB-061 injections for healthy adults and people with moderate-to-severe atopic dermatitis

  This trial will test subcutaneous TRB-061 injections in healthy adults and adults with moderate-to-severe atopic dermatitis to check safety, dosing, and how the drug acts in the body.

  Recruiting at 18 sites Phase 1 TRex Bio, Inc. · Deakin, Australian Capital Territory and 18 other locations · NCT06934252

• Testing VC005 tablets for adults with moderate to severe atopic dermatitis

  This study is testing if VC005 tablets can help adults with moderate to severe eczema feel better and improve their quality of life.

  Recruiting Phase 3 Jiangsu vcare pharmaceutical technology co., LTD · Nanjing, Jiangsu · NCT06723080

• Comparing Methotrexate and Placebo for Treating Atopic Dermatitis in Adults

  This study tests if methotrexate can help adults with moderate to severe atopic dermatitis feel better compared to a placebo when other treatments haven't worked.

  Recruiting at 20 sites Phase 3 medac GmbH · Prague, Praha 1 and 29 other locations · NCT06239311

• National registry for patients with moderate-to-severe atopic dermatitis in Germany

  This study is creating a national registry to track the experiences and treatments of people in Germany with moderate-to-severe atopic dermatitis over two years.

  Recruiting at 3 sites Technische Universität Dresden · Hanover, Lower Saxony and 2 other locations · NCT03057860

Related topics

Quick answers

How many Moderate to Severe Atopic Dermatitis clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (4 trials), China (3 trials), Germany (2 trials), Australia (1 trial), New Zealand (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 5, Phase 2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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