Condition
Melasma clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Melasma clinical trials that are recruiting, at sites in 4 countries (most in El Salvador (1), Puerto Rico (1), Brazil (1)). By phase: Phase 2 (1), Phase 1/2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 4Countries
Newest Melasma clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Face sunscreen with untinted or tinted formula to improve dark spots after 8 weeks | — | Campinas, São Paulo | Recruiting | Jul 1, 2026 |
| Injectable platelet-rich fibrin versus intradermal tranexamic acid for facial melasma | — | Cairo, Cairo Governorate | Recruiting | Apr 20, 2026 |
| Using metformin to treat melasma in Latin American women | Phase 1/2 | San Juan, PR | Recruiting | Feb 25, 2025 |
| Using SM-030 Gel to Treat Melasma in Adults | Phase 2 | Santa Tecla, La Libertad Department and 1 other locations | Recruiting | Jun 12, 2024 |
All recruiting trials (4)
-
Face sunscreen with untinted or tinted formula to improve dark spots after 8 weeks
This study tests whether using a facial sunscreen (untinted or tinted) for 8 weeks can improve facial dark spots in adults with conditions like melasma, solar lentigines, or post-inflammatory hyperpigmentation.
-
Injectable platelet-rich fibrin versus intradermal tranexamic acid for facial melasma
This compares injections of a patient's own platelet-rich fibrin with tiny intradermal tranexamic acid shots to see which reduces facial melasma better in adult women.
-
Using metformin to treat melasma in Latin American women
This study is testing if the diabetes drug metformin can help reduce dark patches on the skin caused by melasma in Latin American women.
-
Using SM-030 Gel to Treat Melasma in Adults
This study is testing two different strengths of a new gel to see if it can help adults with melasma improve their skin, compared to a placebo gel.
Quick answers
How many Melasma clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in El Salvador (1 trial), Puerto Rico (1 trial), Brazil (1 trial), Egypt (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.