Condition

Leptomeningeal Metastasis From Lung Cancer clinical trials and research

• 3Clinical trials
• 1Country

Newest Leptomeningeal Metastasis From Lung Cancer clinical trials

All recruiting trials (3)

• ctDNA-guided Proton Craniospinal Irradiation for EGFR-mutant NSCLC with Leptomeningeal Metastasis

  This trial tests whether a risk-adaptive proton craniospinal irradiation strategy, guided by CSF ctDNA clearance after initial therapy, can improve intracranial progression-free survival in patients with leptomeningeal metastasis from EGFR-mutant NSCLC after resistance to third-generation EGFR inhibitors.

  Recruiting at 3 sites Anhui Provincial Cancer Hospital · Hefei, Anhui and 2 other locations · NCT07751536

• Amivantamab with intrathecal pemetrexed for leptomeningeal metastasis from EGFR-mutated lung adenocarcinoma

  This study tests whether giving amivantamab with intrathecal pemetrexed is safe and may help treat leptomeningeal metastasis in adults with EGFR-mutant lung cancer.

  Recruiting Phase 1/2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07744529

• Intrathecal methotrexate-loaded tumor-derived vesicles for leptomeningeal lung cancer

  This treatment will try giving methotrexate-loaded tumor-derived vesicles into the spinal fluid to see if it is safe and helps adults with leptomeningeal metastasis from lung cancer who have not responded to standard treatments.

  Recruiting Phase 1/2 Henan Cancer Hospital · Zhengzhou, Henan · NCT07559097

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Quick answers

How many Leptomeningeal Metastasis From Lung Cancer clinical trials are recruiting right now?

3, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in China. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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